Structure of PDB 2xk6 Chain A

Receptor sequence
>2xk6A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
RAEDYEVLYTIGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNL
LRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYL
DEEFVLRVMTQLTLALKECHRRSRDLKPANVFLDGKQNVKLGDVGTPYYM
SPEQMNRNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI
PYRYSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB2xk6 Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) D125 K127 A129 N130 D143 T146
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQH A I14 C22 V35 K37 Y70 M86 E87 Y88 C89 E90 G92 D93 F148 I11 C14 V27 K29 Y62 M78 E79 Y80 C81 E82 G84 D85 F132 PDBbind-CN: -logKd/Ki=5.80,IC50=1.6uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xk6, PDBe:2xk6, PDBj:2xk6
PDBsum2xk6
PubMed20936789
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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