Structure of PDB 2xk3 Chain A

Receptor sequence
>2xk3A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEV
NLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQ
YLDEEFVLRVMTQLTLALKECHRRSRDLKPANVFLDGKQNVKLGDFGVGT
PYYMSPEQMNRNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGK
FRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB2xk3 Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) D127 K129 A131 N132 D145 T150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XK3 A I14 C22 V35 E87 C89 G92 F148 D159 F160 I12 C16 V29 E81 C83 G86 F134 D145 F146 PDBbind-CN: -logKd/Ki=5.68,IC50=2.1uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xk3, PDBe:2xk3, PDBj:2xk3
PDBsum2xk3
PubMed20936789
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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