Structure of PDB 2xh9 Chain A

Receptor sequence
>2xh9A (length=420) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
VPTPAEAALAAQTALAADDSPMGDAARWAMGLLTSSRPEDVAARFIPTFN
FAETVREWRSKGPFTVRAYHPVAHKGWVVLSAPAGVRYILSLTLDSSGLI
RILTLKPETVIPDMVTWNDVEETLHTPGVQHSVYAVRLTPDGHEVLHASA
PERPMPTGSAYKLYLMRALVAEIEKGTVGWDEILTLTPELRSLPTGDMQD
LPDGTRVTVRETAHKMIALSDNTGADLVADRLGREVVERSLAAAGHHDPS
LMRPFLTSHEVFELGWGDPERRAEWVRQDEAGRRELLEKMAGVMTVRGSD
LGATVHQLGIDWHMDAFDVVRVLEGLLQDSGRDTSGTVEEILTAYPGLLI
DEERWRRVYFKAGASPGVMMFCWLLQDHAGISYVLVLRQSADEQRLIGDG
LFLRGIGAKIIEAEAKLLSS
3D structure
PDB2xh9 Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J01 A H84 W91 L362 R418 A422 H70 W77 L348 R404 A408
BS02 J01 A K89 T209 S234 Y359 A376 F385 R418 K75 T195 S220 Y345 A362 F371 R404
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2xh9, PDBe:2xh9, PDBj:2xh9
PDBsum2xh9
PubMed23897479
UniProtQ8KRB7

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