Structure of PDB 2xbm Chain A

Receptor sequence
>2xbmA (length=261) Species: 12637 (Dengue virus) [Search protein sequence]
GSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTH
HAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRG
YTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSP
SPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGG
MLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIE
KDVDLGAGTRH
3D structure
PDB2xbm Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5'-Capped Octameric RNA
ChainA
Resolution2.9 Å
3D
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A L17 N18 L20 S21 F25 S151 P152 L15 N16 L18 S19 F23 S149 P150
BS02 SAH A S56 G81 T104 K105 K130 V132 F133 D146 S54 G79 T102 K103 K128 V130 F131 D144
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xbm, PDBe:2xbm, PDBj:2xbm
PDBsum2xbm
PubMed20862256
UniProtC0LMU5

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