Structure of PDB 2xb7 Chain A

Receptor sequence
>2xb7A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
NYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSPLQVAVKT
LPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG
GDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIA
ARNCLLTCPGPGRVAKIGDFGMAAMLPVKWMPPEAFMEGIFTSKTDTWSF
GVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY
3D structure
PDB2xb7 Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1249 A1251 R1253 N1254 D1270
Catalytic site (residue number reindexed from 1) D148 A150 R152 N153 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUI A L1122 H1124 V1130 A1148 K1150 M1199 G1202 E1210 L1256 L28 H30 V36 A47 K49 M98 G101 E109 L155 MOAD: Ki=0.65nM
PDBbind-CN: -logKd/Ki=9.19,Ki=0.65nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xb7, PDBe:2xb7, PDBj:2xb7
PDBsum2xb7
PubMed20695522
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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