Structure of PDB 2xar Chain A

Receptor sequence
>2xarA (length=417) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
MILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQKARRNDSVLT
SDEQHLWRENNELISSPNKEVLEQRYVQNVIIPLLGPKHVDAGVRVSVSK
EFLECVDKKVTKQRPLWRVNAANVDTSHDSALILNDHSLFSQGSGGDCIS
VEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKLEYIEISEESEYDP
LDLFSGSKERVLEAIKALYSTPQNNFRVFLNGSLILGGSGESTGRTSPEI
GYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVLDRLLEIQKLDKLD
IEGAIHCYYDIINQPCPICKEELSLHALPLDESLKIVKEYLIAATAKDCS
IMISFQSRNAWDSEPSGDYVSLKPTNQTFDYKVHFIDLSLKPLKRMESYY
KLDKKIISFYNRKQKAE
3D structure
PDB2xar Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase is a Distant Ipk Member with a Singular Inositide Binding Site for Axial 2-Oh Recognition.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.158: inositol-pentakisphosphate 2-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP A G19 G20 R45 R130 K168 K170 K200 D368 K411 R415 Y419 G17 G18 R43 R118 K154 K156 K186 D348 K391 R395 Y399
BS02 ZN A H320 C330 C333 H346 H306 C316 C319 H326
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0032942 inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
GO:0046872 metal ion binding
GO:0102731 inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
Biological Process
GO:0010264 myo-inositol hexakisphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0030643 intracellular phosphate ion homeostasis
GO:0042742 defense response to bacterium
GO:0048527 lateral root development
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0055062 phosphate ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xar, PDBe:2xar, PDBj:2xar
PDBsum2xar
PubMed20453199
UniProtQ93YN9|IPPK_ARATH Inositol-pentakisphosphate 2-kinase (Gene Name=IPK1)

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