Structure of PDB 2xa4 Chain A

Receptor sequence
>2xa4A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD
FEREIEILKSLQHDNIVKYKGVCYSNLKLIMEYLPYGSLRDYLQAHAERI
DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT
KVLPQDKEYYKVESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIE
KSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIM
TECWNNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB2xa4 Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway
ChainA
Resolution2.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146 S164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZ5 A L855 V863 A880 M929 Y931 L932 G935 N981 L983 G993 L13 V19 A36 M81 Y83 L84 G87 N133 L135 G145 MOAD: ic50<0.003uM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: IC50=58nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2xa4, PDBe:2xa4, PDBj:2xa4
PDBsum2xa4
PubMed21138246
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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