Structure of PDB 2x9f Chain A

Receptor sequence
>2x9fA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
KEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLYTERQRRE
FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDG
QFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFG
LSRFLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWD
MSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSA
LDKMIRNPASLKIVA
3D structure
PDB2x9f Inhibitors of the Tyrosine Kinase Ephb4. Part 3: Identification of Non-Benzodioxole-Based Kinase Inhibitors.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 K781 P783
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148 K158 P160
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X9F A I621 A645 K647 E664 T693 F695 M696 E697 G699 L747 S757 D758 I14 A38 K40 E54 T83 F85 M86 E87 G89 L137 S147 D148 MOAD: ic50=0.061uM
PDBbind-CN: -logKd/Ki=7.21,IC50=61nM
BindingDB: IC50=61nM
BS02 MG A D740 D758 D130 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2x9f, PDBe:2x9f, PDBj:2x9f
PDBsum2x9f
PubMed20850301
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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