Structure of PDB 2x91 Chain A

Receptor sequence
>2x91A (length=595) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
KEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAEL
AKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDT
LSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREF
YDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLED
IFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSE
IADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDF
WDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHEL
GHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKD
YVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAF
WKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYK
SACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALE
AFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS
3D structure
PDB2x91 High Resolution Crystal Structures of Drosophila Melanogaster Angiotensin Converting Enzyme in Complex with Novel Inhibitors and Anti- Hypertensive Drugs.
ChainA
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H337 A338 H367 E368 H371 E395 H497 Y507
Catalytic site (residue number reindexed from 1) H318 A319 H348 E349 H352 E376 H478 Y488
Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LPR A Q265 H337 A338 H367 E368 E395 K495 H497 V502 Y504 Y507 Q246 H318 A319 H348 E349 E376 K476 H478 V483 Y485 Y488 MOAD: Ki=180nM
PDBbind-CN: -logKd/Ki=6.74,Ki=180nM
BS02 ZN A H367 H371 E395 H348 H352 E376
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2x91, PDBe:2x91, PDBj:2x91
PDBsum2x91
PubMed20488190
UniProtQ10714|ACE_DROME Angiotensin-converting enzyme (Gene Name=Ance)

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