Structure of PDB 2x8p Chain A

Receptor sequence

>2x8pA (length=311) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]

NTTGGRFVDKDNRKYYVKDDHKAIYWHKIDGKTYYFGDIGEMVVGWQYLE
IPGTGYRDNLFDNQPVNEIGLQEKWYYFGQDGALLEQTDKQVLEAKTSEN
TGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYEDGNWYYLNKLGNFGDDS
YNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKMLTDWQKVNGK
WYYFGSSGSMATGWKYVRGKWYYLDNKNGDMKTGWQYLGNKWYYLRSSGA
MVTGWYQDGLTWYYLNAGNGDMKTGWFQVNGKWYYAYSSGALAVNTTVDG
YSVNYNGEWVQ

3D structure

PDB

2x8p Crystal Structures of Cbpf Complexed with Atropine and Ipratropium Reveal Clues for the Design of Novel Antimicrobials Against Streptococcus Pneumoniae.

Chain

Resolution

2.27 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V126
Catalytic site (residue number reindexed from 1)	V126
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	OIN	A	W194 K196 W201	W194 K196 W201
BS02	OIN	A	W163 W181 K227 N228	W163 W181 K227 N228
BS03	CHT	A	W283 Y301 W309	W283 Y301 W309
BS04	CHT	A	W235 W242	W235 W242
BS05	CHT	A	W214 W221 N269	W214 W221 N269

External links

PDB	RCSB:2x8p, PDBe:2x8p, PDBj:2x8p
PDBsum	2x8p
PubMed	24036328
UniProt	Q8DR52

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