Structure of PDB 2x6v Chain A

Receptor sequence
>2x6vA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
GIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYIL
LMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQL
VSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADTAFCTHVFPETAF
IAVTSYQNHKITQLKIENNPFAKGFRG
3D structure
PDB2x6v Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S175 T215 P231 F232 K234 G235 S123 T154 P170 F171 K173 G174 PDBbind-CN: Kd=109nM
BS02 dna A R81 R82 K159 Y217 T223 K226 I227 N230 F232 F236 R29 R30 K107 Y156 T162 K165 I166 N169 F171 F175 PDBbind-CN: Kd=109nM
BS03 MG A E60 S86 K88 E8 S34 K36
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2x6v, PDBe:2x6v, PDBj:2x6v
PDBsum2x6v
PubMed20450920
UniProtQ99593|TBX5_HUMAN T-box transcription factor TBX5 (Gene Name=TBX5)

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