Structure of PDB 2x6i Chain A

Receptor sequence
>2x6iA (length=546) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
ASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCIN
WKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAP
DEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPANLCTFLIQRACTNATLA
NYFYWYLSIEVEERKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLR
KQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPI
PFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDD
LRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTV
AEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLG
VGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGI
SSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVK
KVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWR
3D structure
PDB2x6i Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 090 A K674 I696 K698 D706 Y732 Y746 V747 S749 L812 I822 D823 K272 I294 K296 D304 Y330 Y344 V345 S347 L410 I420 D421 PDBbind-CN: -logKd/Ki=6.08,IC50=830nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2x6i, PDBe:2x6i, PDBj:2x6i
PDBsum2x6i
PubMed20339072
UniProtQ9W1M7

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