Structure of PDB 2x4f Chain A

Receptor sequence
>2x4fA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGQVHKCEETATGLKLAA
KIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVD
GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENIL
CVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPT
DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEA
KEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQ
3D structure
PDB2x4f The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156
ChainA
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D227 K229 E231 N232 D247 T266
Catalytic site (residue number reindexed from 1) D143 K145 E147 N148 D163 T182
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 16X A L112 V120 Y182 V183 G186 L33 V36 Y98 V99 G102
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004687 myosin light chain kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2x4f, PDBe:2x4f, PDBj:2x4f
PDBsum2x4f
PubMed
UniProtQ86YV6|MYLK4_HUMAN Myosin light chain kinase family member 4 (Gene Name=MYLK4)

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