Structure of PDB 2x4d Chain A

Receptor sequence
>2x4dA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
SMAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLK
VRFCTNESAASRAELVGQLQRLGFDISEQEVTAPAPAACQILKERGLRPY
LLIHDGVRSEFDQIDTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPV
LISLGKGRYYAATSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSAL
QAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRPSDEHHPEVK
ADGYVDNLAEAVDLLLQHAD
3D structure
PDB2x4d Crystal Structure of Human Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase Lhpp
ChainA
Resolution1.92 Å
3D
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Enzymatic activity
Enzyme Commision number 3.1.3.-
3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 POP A D17 I18 S19 T54 N55 E56 K189 D18 I19 S20 T55 N56 E57 K190
BS02 MG A D17 S19 D214 D18 S20 D215
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck

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Cellular Component
External links
PDB RCSB:2x4d, PDBe:2x4d, PDBj:2x4d
PDBsum2x4d
PubMed
UniProtQ9H008|LHPP_HUMAN Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (Gene Name=LHPP)

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