Structure of PDB 2x2e Chain A

Receptor sequence
>2x2eA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRD
FLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAET
DRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQ
IRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVIT
KLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAE
RKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLL
SIEKEVEEYKNFRPDKHGTDSRVDEMLRMYHALKEALSIIG
3D structure
PDB2x2e G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A S41 G43 K44 S45 S46 R59 G60 K206 D208 L209 V235 N236 R237 S238 Q239 S36 G38 K39 S40 S41 R54 G55 K201 D203 L204 V230 N231 R232 S233 Q234
BS02 ALF A S41 K44 V64 T65 G139 S36 K39 V59 T60 G134
BS03 MG A S45 T65 S40 T60
BS04 NA A S41 G60 S61 G62 V64 S36 G55 S56 G57 V59
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2e, PDBe:2x2e, PDBj:2x2e
PDBsum2x2e
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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