Structure of PDB 2wzb Chain A

Receptor sequence
>2wzbA (length=405) Species: 9606 (Homo sapiens) [Search protein sequence]
LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLD
NGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGP
EVEKACANPAAGSVILLENLRFHVEEEGKGEPAKIEAFRASLSKLGDVYV
NDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAIL
GGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEG
AKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWM
GLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKA
TSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVD
ALSNI
3D structure
PDB2wzb Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis.
ChainA
Resolution1.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R38 K215 G373 G396
Catalytic site (residue number reindexed from 1) R37 K204 G362 G385
Enzyme Commision number 2.7.2.3: phosphoglycerate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G213 A214 K215 K219 G237 G238 N336 P338 G340 V341 E343 G372 D374 T375 G202 A203 K204 K208 G226 G227 N325 P327 G329 V330 E332 G361 D363 T364
BS02 MGF A K215 K219 G372 G395 G396 K204 K208 G361 G384 G385
Gene Ontology
Molecular Function
GO:0004618 phosphoglycerate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0043531 ADP binding
GO:0047134 protein-disulfide reductase (NAD(P)H) activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0030855 epithelial cell differentiation
GO:0031639 plasminogen activation
GO:0061621 canonical glycolysis
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0045121 membrane raft
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wzb, PDBe:2wzb, PDBj:2wzb
PDBsum2wzb
PubMed20397725
UniProtP00558|PGK1_HUMAN Phosphoglycerate kinase 1 (Gene Name=PGK1)

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