Structure of PDB 2wyj Chain A

Receptor sequence
>2wyjA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMN
VAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDR
NSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIV
SWGEGCARKGKYGIYTKVTAFLKWIDRSMK
3D structure
PDB2wyj Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Monoaryl P4 Motifs
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D85 Q179 G180 D181 S182 G183
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 898 A T98 Y99 F174 D189 A190 Q192 V213 W215 G216 G219 G226 I227 Y228 T81 Y82 F159 D176 A177 Q179 V200 W202 G203 G205 G213 I214 Y215 MOAD: Ki=1nM
PDBbind-CN: -logKd/Ki=9.00,Ki=1nM
BindingDB: Ki=0.8nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wyj, PDBe:2wyj, PDBj:2wyj
PDBsum2wyj
PubMed20006499
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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