Structure of PDB 2wyg Chain A

Receptor sequence
>2wygA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAP
ACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC
KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWG
EGCARKGKYGIYTKVTAFLKWIDRSMKT
3D structure
PDB2wyg Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Monoaryl P4 Motifs
ChainA
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D82 Q176 G177 D178 S179 G180
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 461 A E97 Y99 F174 D189 A190 Q192 V213 W215 G216 G226 I227 Y228 E77 Y79 F156 D173 A174 Q176 V197 W199 G200 G210 I211 Y212 MOAD: Ki=2nM
PDBbind-CN: -logKd/Ki=8.70,Ki=2nM
BindingDB: Ki=2nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wyg, PDBe:2wyg, PDBj:2wyg
PDBsum2wyg
PubMed20006499
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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