Structure of PDB 2wxt Chain A

Receptor sequence
>2wxtA (length=359) Species: 1502 (Clostridium perfringens) [Search protein sequence]
WDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQL
GSTYPDYDKNAYDLYQDHFWDPDTLAYSIPDTGESQIRKFSALARYEWQR
GNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQ
YKINTAGCKTNEAFYTDILKNKDFNAWSKEYARGFAKTGKSIYYSHASMS
HSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAY
ISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKL
KDENLKIDDIQNMWIRKRKYTAFSDAYKPENIKIIANGKVVVDKDINEWI
SGNSTYNIK
3D structure
PDB2wxt Comparison of a Nontoxic Variant of Clostridium Perfringens [Alpha]-Toxin with the Toxic Wild-Type Strain
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H11 D56 H68 H126 D130 H136 H148 E152
Catalytic site (residue number reindexed from 1) H11 D56 H68 H115 D119 H125 H137 E141
Enzyme Commision number 3.1.4.3: phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A W1 H11 D130 W1 H11 D119
BS02 CA A D273 N297 D262 N286
Gene Ontology
Molecular Function
GO:0004629 phospholipase C activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0034480 phosphatidylcholine phospholipase C activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0031640 killing of cells of another organism
GO:0035821 modulation of process of another organism
GO:0044179 hemolysis in another organism
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2wxt, PDBe:2wxt, PDBj:2wxt
PDBsum2wxt
PubMed20944240
UniProtQ0TV31|PHLC_CLOP1 Phospholipase C (Gene Name=plc)

[Back to BioLiP]