Structure of PDB 2wxg Chain A

Receptor sequence
>2wxgA (length=835) Species: 10090 (Mus musculus) [Search protein sequence]
VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLG
WVEWLQYSFPLQLEPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACAL
RKKATVFRQPLEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTP
HLTMVHSSSILAMRDEQSNLWSLEQPFSIELIEGRKVNAMKLVVQAGLFH
GNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVD
CPIAWANLMLFDYKDQLKTGERCLYMWPSVELLNPAGTVRGNPNTESAAA
LVIYLPEVAPVYFPALEKILELEEELREILERSGELYEHEKDLVWKMRHE
VQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSF
PDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRA
LANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGE
ALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDP
STLLEEVCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQD
MLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANI
QLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATY
VLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKNRERVPFILTYDFVHVI
QQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS
KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW
3D structure
PDB2wxg The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZZN A F751 M752 P758 W760 I777 K779 D787 Y813 I825 V828 D832 T833 M900 I910 D911 F564 M565 P571 W573 I590 K592 D600 Y626 I638 V641 D645 T646 M713 I723 D724 MOAD: ic50=0.7nM
PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wxg, PDBe:2wxg, PDBj:2wxg
PDBsum2wxg
PubMed20081827
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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