Structure of PDB 2wwy Chain A

Receptor sequence
>2wwyA (length=530) Species: 9606 (Homo sapiens) [Search protein sequence]
SSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLV
MPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLN
ASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARR
FTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVL
TDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRY
KGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSA
NEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKA
DCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHF
DEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTP
LKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFT
AYATISYLKIGPKANLLNNEAHAITMQVTK
3D structure
PDB2wwy Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D230 R232 Q324 A346 A373 M429 A525 D168 R170 Q262 A284 A311 M367 A463
BS02 dna A M199 K206 M137 K144
BS03 ZN A C453 C471 C475 C478 C391 C409 C413 C416
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wwy, PDBe:2wwy, PDBj:2wwy
PDBsum2wwy
PubMed25831490
UniProtP46063|RECQ1_HUMAN ATP-dependent DNA helicase Q1 (Gene Name=RECQL)

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