Structure of PDB 2wwu Chain A

Receptor sequence
>2wwuA (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
VKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLK
KDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYY
YSGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERP
NVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLF
ECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLA
FGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIF
RGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQL
IKDLAREIRLVED
3D structure
PDB2wwu Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.65: [histone H3]-dimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A H247 I248 Q288 T355 H168 I169 Q209 T276
BS02 BGC A Y179 Y180 R184 D326 Y100 Y101 R105 D247
External links
PDB RCSB:2wwu, PDBe:2wwu, PDBj:2wwu
PDBsum2wwu
PubMed20067792
UniProtQ9UPP1|PHF8_HUMAN Histone lysine demethylase PHF8 (Gene Name=PHF8)

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