Structure of PDB 2wwb Chain A

Receptor sequence
>2wwbA (length=476) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPL
FGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKII
EVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLL
ITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTT
VNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIF
VFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN
LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLSPPES
FGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMV
MRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLA
VTIIYQYFEIFVKEQSEVGSMGALLF
3D structure
PDB2wwb Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome.
ChainA
Resolution6.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna A Y272 R273 Y276 Y272 R273 Y276
BS02 rna A R271 R273 R402 G403 H404 R405 E406 R271 R273 R402 G403 H404 R405 E406
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2wwb, PDBe:2wwb, PDBj:2wwb
PDBsum2wwb
PubMed19933108
UniProtP38377|S61A1_CANLF Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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