Structure of PDB 2ww5 Chain A

Receptor sequence

>2ww5A (length=431) Species: 171101 (Streptococcus pneumoniae R6)

AAAYWDGDYYVKDDGSKAQSEWIFDNYYKAWFYINSDGRYSQNEWHGNYY
LKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGNKWYYFKKWGY
MAKSQWQGSYFLNGQGAMIQNEWLYDPAYSAYFYLKSDGTYANQEWQKVG
GKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGARYIFAASGELK
EKKDLNVGWVHRDGKRYFFNNREEQVGTEHAKKIIDISEHNGRINDWKKV
IDENEVDGVIVRLGYSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETD
AENDAKQTIELIKKYNMNLSYPIYYDVENWEYVNKSKRAPSDTDTWVKII
NKYMDTMKQAGYQNVYVYSYRSLLQTRLKHPDILKHVNWVAAYTNALEWE
NPYYSGEKGWQYTSSEYMKGIQGRVDVSVWY

3D structure

• PDB: 2ww5 Insights Into Pneumococcal Fratricide from the Crystal Structures of the Modular Killing Factor Lytc.
• Chain: A
• Resolution: 1.61 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y117
• Catalytic site (residue number reindexed from 1): Y80
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CHT	A	W42 Y65 F69 Y77 G91 Y93	W5 Y28 F32 Y40 G54 Y56
BS02	CHT	A	W59 W68 Y86 D114	W22 W31 Y49 D77
BS03	CHT	A	W82 G84 Y105 F109 Y117 W135	W45 G47 Y68 F72 Y80 W98
BS04	CHT	A	W99 W108 Y130 Q152	W62 W71 Y93 Q115
BS05	CHT	A	W122 W129 Y147	W85 W92 Y110
BS06	CHT	A	W143 G145 Y166 F170 Y178 W196	W106 G108 Y129 F133 Y141 W159
BS07	CHT	A	W160 Y169 Y191 S213	W123 Y132 Y154 S176

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0009253 peptidoglycan catabolic process
• GO:0016052 carbohydrate catabolic process
• GO:0016998 cell wall macromolecule catabolic process

External links

• PDB: RCSB:2ww5, PDBe:2ww5, PDBj:2ww5
• PDBsum: 2ww5
• PubMed: 20400948
• UniProt: Q8DP07