Structure of PDB 2ww4 Chain A

Receptor sequence
>2ww4A (length=283) Species: 562 (Escherichia coli) [Search protein sequence]
MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDDGD
IRLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLPTGSGANISIDKRLPM
GGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLTLGADVPVFVRGHA
AFAEGVGEILTPVDPPEKWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIE
TLLKCEFSNDCEVIARKRFREVDAVLSWLLEYAPSRLTGTGACVFAEFDT
ESEARQVLEQAPEWLNGFVAKGVNLSPLHRAML
3D structure
PDB2ww4 A Triclinic Crystal Form of Escherichia Coli 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase and Reassessment of the Quaternary Structure.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K10 D141
Catalytic site (residue number reindexed from 1) K10 D141
Enzyme Commision number 2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N65 L66 K96 M100 G101 G105 G106 G107 S108 N110 N65 L66 K96 M100 G101 G105 G106 G107 S108 N110
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:2ww4, PDBe:2ww4, PDBj:2ww4
PDBsum2ww4
PubMed20208151
UniProtP62615|ISPE_ECOLI 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (Gene Name=ispE)

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