Structure of PDB 2wv2 Chain A

Receptor sequence
>2wv2A (length=443) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
TDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTI
VGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNF
LAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTA
CQCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARC
HEARTELQKILSEIIIARKEEEVTSDLLSGLLSAVYRDGTPMSLHEVCGM
IVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNN
VMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSP
LLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKT
ILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRK
3D structure
PDB2wv2 Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.70: Transferred entry: 1.14.14.154.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPF A Y103 Y116 A291 L356 Y74 Y87 A257 L322 BindingDB: Kd=3.4e+2nM
BS02 HEM A Y116 L127 A291 G292 T295 L356 L359 R361 G414 F415 H420 C422 I423 G424 Y87 L98 A257 G258 T261 L322 L325 R327 G380 F381 H386 C388 I389 G390
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008398 sterol 14-demethylase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0016125 sterol metabolic process
GO:0044091 membrane biogenesis
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum

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Molecular Function
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Cellular Component
External links
PDB RCSB:2wv2, PDBe:2wv2, PDBj:2wv2
PDBsum2wv2
PubMed20386598
UniProtQ385E8

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