Structure of PDB 2wuc Chain A

Receptor sequence
>2wucA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDS
VSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKG
DRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREA
LVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKN
GVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR
3D structure
PDB2wuc Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D90 Q188 G189 D190 S191 G192
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S26 W29 R114 Q116 P120 C122 V206 A207 I242 R243 S11 W14 R106 Q108 P112 C114 V202 A203 I238 R239
BS02 peptide A H57 S99 D189 A190 C191 Q192 S195 S214 W215 G216 D217 H40 S87 D185 A186 C187 Q188 S191 S210 W211 G212 D213
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wuc, PDBe:2wuc, PDBj:2wuc
PDBsum2wuc
PubMed20004165
UniProtQ04756|HGFA_HUMAN Hepatocyte growth factor activator (Gene Name=HGFAC)

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