Structure of PDB 2wub Chain A

Receptor sequence
>2wubA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDS
VSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKG
DRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREA
LVPLVADHKCSSPEVYGADISPNMLCAGYFDCACQGDSGGPLACEKNGVA
YLYGIISWGCGKPGVYTRVANYVDWINDRIR
3D structure
PDB2wub Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D90 Q185 G186 D187 S188 G189
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W29 Q116 P120 I121 C122 E202 A207 I242 R243 W14 Q108 P112 I113 C114 E195 A200 I230 R231
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2wub, PDBe:2wub, PDBj:2wub
PDBsum2wub
PubMed20004165
UniProtQ04756|HGFA_HUMAN Hepatocyte growth factor activator (Gene Name=HGFAC)

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