Structure of PDB 2wu7 Chain A

Receptor sequence
>2wu7A (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
SVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVA
LKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCI
AFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDL
KPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV
MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSY
MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSF
3D structure
PDB2wu7 Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D283 K285 N288 D320 T337
Catalytic site (residue number reindexed from 1) D149 K151 N154 D186 T203
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V25 A L162 G163 E164 V170 A184 K186 L239 E287 L290 L28 G29 E30 V36 A50 K52 L105 E153 L156 MOAD: ic50=530nM
PDBbind-CN: -logKd/Ki=6.28,IC50=530nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wu7, PDBe:2wu7, PDBj:2wu7
PDBsum2wu7
PubMed21276940
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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