Structure of PDB 2wu6 Chain A

Receptor sequence
>2wu6A (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
RSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQV
ALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMC
IAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTD
LKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTT
IVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL
VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKS
YMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFH
3D structure
PDB2wu6 Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D283 K285 N288 D320 T337
Catalytic site (residue number reindexed from 1) D150 K152 N155 D187 T204
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DKI A L162 V170 A184 V220 F236 L239 G240 K241 L290 D320 L29 V37 A51 V87 F103 L106 G107 K108 L157 D187 MOAD: ic50=29.2nM
PDBbind-CN: -logKd/Ki=7.53,IC50=29.2nM
BindingDB: IC50=29nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wu6, PDBe:2wu6, PDBj:2wu6
PDBsum2wu6
PubMed21276940
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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