Structure of PDB 2wtw Chain A

Receptor sequence
>2wtwA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ
LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLSK
FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGW
SVHAPSCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANT
YQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
TANSSK
3D structure
PDB2wtw Crystal Structure of an Aurora-A Mutant that Mimics Aurora-B Bound to Mln8054: Insights Into Selectivity and Drug Design.
ChainA
Resolution3.302 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D129 K131 E133 N134 D147 T159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZZL A R137 G140 V147 K162 L194 L210 Y212 A213 G216 L263 A273 D274 R10 G13 V20 K35 L67 L83 Y85 A86 G89 L136 A146 D147 PDBbind-CN: -logKd/Ki=8.19,Kd=6.5nM
BindingDB: IC50=34nM,Kd=6.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:2wtw, PDBe:2wtw, PDBj:2wtw
PDBsum2wtw
PubMed20067443
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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