Structure of PDB 2wtc Chain A

Receptor sequence
>2wtcA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
VYPKALRDEYIMSKTLGSEVKLAFERKTCKKVAIKIISKPALNVETEIEI
LKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL
YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILT
SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS
EHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTE
EALRHPWLQDEDMKRKFQDLLSEENESTALPQVL
3D structure
PDB2wtc Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D347 K349 N352 D368 T387
Catalytic site (residue number reindexed from 1) D121 K123 N126 D142 T159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VGM A L226 K249 L301 L303 M304 G307 L354 T367 D368 L16 K35 L75 L77 M78 G81 L128 T141 D142 PDBbind-CN: -logKd/Ki=6.51,IC50=0.31uM
BindingDB: IC50=310nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wtc, PDBe:2wtc, PDBj:2wtc
PDBsum2wtc
PubMed20022510
UniProtO96017|CHK2_HUMAN Serine/threonine-protein kinase Chk2 (Gene Name=CHEK2)

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