Structure of PDB 2wt4 Chain A

Receptor sequence
>2wt4A (length=315) Species: 210 (Helicobacter pylori) [Search protein sequence]
LPTIALLATGGTIAGSGGVKELLKAIPSLNKIARIQGEQVSNIGSQDMNE
EIWFKLAQRAQELLDDSRIQGVVITHGTDTLEESAYFLNLVLHSTKPVVL
VGAMRNASSLSADGALNLYEAVSVAVNEKSANKGVLVVMDDTIFSVREVV
KTHTTHVSTFKALNSGAIGSVYYGKTRYYMQPLRKHTTESEFSLSQLKTP
LPKVDIIYTHAGMTPDLFQASLNSHAKGVVIAGVGNGNVSAGFLKAMQEA
SQMGVVIVRSSRVGSGGVTSGEIDDKAYGFITSDNLNPQKARVLLQLALT
KTNDKAKIQEMFEEY
3D structure
PDB2wt4 Structure of Helicobacter Pylori L-Asparaginase at 1.4 A Resolution
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T16 T95 D96 K168 E289
Catalytic site (residue number reindexed from 1) T12 T78 D79 K151 E272
Enzyme Commision number 3.5.1.1: asparaginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A T16 G61 S62 Q63 G94 T95 D96 T12 G44 S45 Q46 G77 T78 D79
Gene Ontology
Molecular Function
GO:0004067 asparaginase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006528 asparagine metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2wt4, PDBe:2wt4, PDBj:2wt4
PDBsum2wt4
PubMed19966411
UniProtQ9ZLB9|ASPG_HELPJ Probable L-asparaginase (Gene Name=ansA)

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