Structure of PDB 2wr8 Chain A

Receptor sequence
>2wr8A (length=258) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
GSHMITLTTDFGLKGPYVGEMKVAMLRINPNAKIVDVTHSVTRHSILEGS
FVMEQVVKYSPKGTVHVGVIDPGVGERRAIVIEGDQYLVVPDNGLATLPL
KHIKVKSVYEIIPDKIRKFTGWEISSTFHGRDIFGPAGALIEKGIHPEEF
GREIPVDSIVKLNVEPRKEGDVWILKVIYIDDFGNVILNLENYEKPRTVE
LLDFNLRLPYLETYGLVEKGEMLALPGSHDYLEIAVNMGSAAERLNVKVG
DELRVRLL
3D structure
PDB2wr8 Mechanistic Insights Into Water Activation in Sam Hydroxide Adenosyltransferase (Duf-62).
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.13.2.3: (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 SAH A F181 N183 Y212 S226 E231 M236 F183 N185 Y214 S228 E233 M238 MOAD: Ki=3.6uM
PDBbind-CN: -logKd/Ki=5.44,Ki=3.6uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2wr8, PDBe:2wr8, PDBj:2wr8
PDBsum2wr8
PubMed19739191
UniProtO58212|RSAMH_PYRHO (R)-S-adenosyl-L-methionine hydrolase (Gene Name=PH0463)

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