Structure of PDB 2wr4 Chain A

Receptor sequence
>2wr4A (length=485) Species: 11309 (unidentified influenza virus) [Search protein sequence]
QICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCRLSGIPPLE
LGDCSIAGWLLGNPECDRLLSVPEWSYIVEKENPTNGLCYPGSFNDYEEL
KHLLTSVTHFEKIKILPRDQWTQHTTTGGSRACAVSGNPSFFRNMVLTKK
GSNYPVAKRSYNNTSGEQMLIIWGIHYPNDDTEQRTLYQNVGTYVSVGTS
TLNKRSIPEIATRPKVNGQGGRMEFSWTLLETWDVINFESTGNLIAPEYG
FKISKRGSSGIMKTEKTLENCETKCQTPLGAINTTLPFHNIHPLTIGECP
KYVKSDRLVLATGLRNVPGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGS
GYAADKESTQKAFDGITNKVNSVIAKMNTQFEAVGKEFSNLERRLENLNK
KMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKE
LGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEESK
3D structure
PDB2wr4 From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.1.53: sialate O-acetylesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A Y95 G134 S135 R136 H182 E189 L193 Q225 Y90 G129 S130 R131 H176 E183 L187 Q219
Gene Ontology
Molecular Function
GO:0001681 sialate O-acetylesterase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046761 viral budding from plasma membrane
GO:0075512 clathrin-dependent endocytosis of virus by host cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2wr4, PDBe:2wr4, PDBj:2wr4
PDBsum2wr4
PubMed19805083
UniProtD0VWP9

[Back to BioLiP]