Structure of PDB 2wqy Chain A

Receptor sequence

>2wqyA (length=613) Species: 9031 (Gallus gallus) [Search protein sequence]

STQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTV
AAQGGINAALGNMEDDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVI
ELENYGMPFSRTEEGKIYQRAFGGQSLQFGKGGQAHRCCCVADRTGHSLL
HTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGTIHRFRAKN
TVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIY
GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTIEI
REGRGCGPEKDHVYLQLHHLPPQQLATRLPGISETAMIFAGVDVTKEPIP
VLPTVHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEAASASVHGANR
LGANSLLDLVVFGRACALTIAETCKPGEPVPSIKPNAGEESVANLDKLRF
ADGTIRTSEARLNMQKTMQSHAAVFRTGSILQEGCEKLSQIYRDLAHLKT
FDRGIVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKLRI
DEFDYSKPLQGQQKRPFEEHWRKHTLSYVDVKSGKVTLKYRPVIDRTLNE
EDCSSVPPAIRSY

3D structure

PDB

2wqy 3-Nitropropionic Acid is a Suicide Inhibitor of Mitochondrial Respiration that, Upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme.

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F130 Q251 H253 L263 E266 R269 R297 H364 Y365 R408
Catalytic site (residue number reindexed from 1)	F122 Q243 H245 L255 E258 R261 R289 H356 Y357 R400
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AZI	A	Y172 V174	Y164 V166
BS02	FAD	A	G25 A26 G27 A29 T48 K49 S55 H56 T57 A59 A60 Q61 G62 G63 F177 A178 A212 T213 D232 L263 H364 Y365 G396 E397 A411 S413 L414 L417	G17 A18 G19 A21 T40 K41 S47 H48 T49 A51 A52 Q53 G54 G55 F169 A170 A204 T205 D224 L255 H356 Y357 G388 E389 A403 S405 L406 L409
BS03	OAA	A	G62 H253 L263 T265 E266 R297 H364 R408 G410 A411	G54 H245 L255 T257 E258 R289 H356 R400 G402 A403

Gene Ontology

	Molecular Function
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2wqy, PDBe:2wqy, PDBj:2wqy
PDBsum	2wqy
PubMed
UniProt	Q9YHT1\|SDHA_CHICK Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)

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