Structure of PDB 2wqe Chain A

Receptor sequence
>2wqeA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQRKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADGT
LDYLPPEMIDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT
FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS
3D structure
PDB2wqe A Cancer Associated Aurora-A Mutant is Mislocalised and Misregulated due to Loss of Interaction with Tpx2.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 T150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G140 K141 G142 V147 A160 K162 E211 A213 L263 G14 K15 G16 V21 A34 K36 E85 A87 L137
BS02 ADP A I158 Y212 S266 I32 Y86 S140
BS03 ADP A R155 F157 R195 Y197 R29 F31 R69 Y71
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:2wqe, PDBe:2wqe, PDBj:2wqe
PDBsum2wqe
PubMed19801554
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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