Structure of PDB 2wnc Chain A

Receptor sequence
>2wncA (length=215) Species: 6500 (Aplysia californica) [Search protein sequence]
DDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADS
STNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSS
TRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFG
SWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPY
IDVNLVVKFRERRAG
3D structure
PDB2wnc Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TKT A Y93 W147 Y188 C190 Y195 Y98 W152 Y193 C195 Y200 MOAD: Kd=479nM
PDBbind-CN: -logKd/Ki=6.32,Kd=479nM
BS02 TKT A Q57 M116 I118 Q62 M121 I123 MOAD: Kd=479nM
PDBbind-CN: -logKd/Ki=6.32,Kd=479nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2wnc, PDBe:2wnc, PDBj:2wnc
PDBsum2wnc
PubMed19696737
UniProtQ8WSF8

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