Structure of PDB 2wnb Chain A

Receptor sequence
>2wnbA (length=273) Species: 9823 (Sus scrofa) [Search protein sequence]
RPCTCTRCIEEQRVSAWFDERFNRSMQPLLTAKNAHLEEDTYKWWLRLQR
EKQPNNLNDTIRELFQVVPGNVDPLLEKRLVSCRRCAVVGNSGNLKESYY
GPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQEVSMIL
VPFKTTDLEWVISATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVF
DRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWHHYWEGVHD
GDFESNVTTILASINKIRIFKGR
3D structure
PDB2wnb Structural Insight Into Mammalian Sialyltransferases.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y269 H319
Catalytic site (residue number reindexed from 1) Y210 H249
Enzyme Commision number 2.4.3.2: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase.
2.4.3.4: beta-galactoside alpha-2,3-sialyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A Q108 Y194 F212 Y233 Y269 H319 Q49 Y135 F153 Y174 Y210 H249
BS02 C5P A N150 S151 M172 N173 G273 F292 G293 W300 H302 N91 S92 M113 N114 G214 F233 G234 W241 H243
Gene Ontology
Molecular Function
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wnb, PDBe:2wnb, PDBj:2wnb
PDBsum2wnb
PubMed19820709
UniProtQ02745|SIA4A_PIG CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Gene Name=ST3GAL1)

[Back to BioLiP]