Structure of PDB 2wmw Chain A

Receptor sequence
>2wmwA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
EDWDLVQTLGVQLAVNRVTEEAVAVKIVDMNIKKEICINKMLNHENVVKF
YGHRREIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH
GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLP
YVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWK
EKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL
3D structure
PDB2wmw Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.
ChainA
Resolution2.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 E134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D108 K110 E112 N113 D126 T148
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZYW A V23 A36 Y86 C87 L137 V11 A24 Y64 C65 L115 MOAD: ic50=0.39uM
PDBbind-CN: -logKd/Ki=6.41,IC50=0.39uM
BindingDB: IC50=390nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wmw, PDBe:2wmw, PDBj:2wmw
PDBsum2wmw
PubMed19572549
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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