Structure of PDB 2wms Chain A

Receptor sequence
>2wmsA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
EDWDLVQTLGEVQLAVNRVTEEAVAVKINIKKEICINKMLNHENVVKFYG
HRQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGIT
HRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE
LLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY
LNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLK
3D structure
PDB2wms Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 E134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D103 K105 E107 N108 D121 T143
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZYS A L15 A36 Y86 C87 G90 L137 L9 A25 Y59 C60 G63 L110
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wms, PDBe:2wms, PDBj:2wms
PDBsum2wms
PubMed19572549
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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