Structure of PDB 2wk1 Chain A

Receptor sequence
>2wk1A (length=242) [Search protein sequence]
DSSLYLDLMIKVLAGTVYEDPAHRETYREEVRNEGRDWPANAHTMIGIKR
LENIRQCVEDVIGNNVPGDLVETGVWRGGACILMRGILRAHDVRDRTVWV
ADSFQGIPDVGEDGYAGDRKMALHRRNSVLAVSEEEVRRNFRNYDLLDEQ
VRFLPGWFKDTLPTAPIDTLAVLRMDGDLYESTWDTLTNLYPKVSVGGYV
IVDDYMMCPPCKDAVDEYRAKFDIADELITIDRDGVYWQRTR
3D structure
PDB2wk1 The Crystal Structure of the Novobiocin Biosynthetic Enzyme Novp: The First Representative Structure for the Tylf O-Methyltransferase Superfamily.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.285: demethyldecarbamoylnovobiocin O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A T64 M65 I66 E92 G94 V95 W96 D122 S123 G126 P128 W177 F178 D196 G197 S202 T44 M45 I46 E72 G74 V75 W76 D102 S103 G106 P108 W157 F158 D176 G177 S182
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation
GO:0043642 novobiocin biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wk1, PDBe:2wk1, PDBj:2wk1
PDBsum2wk1
PubMed19857499
UniProtQ9L9F2|NOVP_STRNV Demethyldecarbamoylnovobiocin O-methyltransferase (Gene Name=novP)

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