Structure of PDB 2wjf Chain A

Receptor sequence
>2wjfA (length=244) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
GMIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFE
TPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTL
NDSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKR
VRELIDMGCYTQVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASD
MHNLDGRPPHMAEAYDLVTQKYGEAKAQELFIDNPRKIVMDQLI
3D structure
PDB2wjf Crystal Structures of Wzb of Escherichia Coli and Cpsb of Streptococcus Pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A H42 R139 D199 H201 R206 H43 R140 D200 H202 R207
BS02 MN A E80 E108 H136 E81 E109 H137
BS03 MN A H5 H7 E80 D199 H6 H8 E81 D200
BS04 MN A H7 D14 H42 H201 H8 D15 H43 H202
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0030145 manganese ion binding
Biological Process
GO:0000271 polysaccharide biosynthetic process
GO:0045227 capsule polysaccharide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2wjf, PDBe:2wjf, PDBj:2wjf
PDBsum2wjf
PubMed19616007
UniProtQ9AHD4|CPSB_STRPN Tyrosine-protein phosphatase CpsB (Gene Name=cpsB)

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