Structure of PDB 2wgi Chain A

Receptor sequence
>2wgiA (length=234) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFK
IPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVF
QQIAREVGEVRMQKYLKKFSYGNALEGQLRISAVNQVEFLESLYLNKLSA
SKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKET
EVYFFAFNMDIDNESKLPLRKSIPTKIMESEGII
3D structure
PDB2wgi Critical Role of Tryptophan 154 for the Activity and Stability of Class D Beta-Lactamases.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S67 K70 S115 F120 A154 F208
Catalytic site (residue number reindexed from 1) S47 K50 S95 F100 A124 F178
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNM A S67 S115 L155 T206 F208 R250 S47 S95 L125 T176 F178 R220 PDBbind-CN: -logKd/Ki=4.07,Kd=85uM
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2wgi, PDBe:2wgi, PDBj:2wgi
PDBsum2wgi
PubMed19860471
UniProtP14489|BLO10_PSEAI Beta-lactamase OXA-10 (Gene Name=bla)

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