Structure of PDB 2wfx Chain A

Receptor sequence
>2wfxA (length=152) Species: 10090 (Mus musculus) [Search protein sequence]
LTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKD
EENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEES
LHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE
NS
3D structure
PDB2wfx Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H141 D148 H183 H102 D109 H144
BS02 CA A E90 E91 D96 T126 E127 E51 E52 D57 T87 E88
BS03 CA A E91 E127 D130 E52 E88 D91
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:2wfx, PDBe:2wfx, PDBj:2wfx
PDBsum2wfx
PubMed19561611
UniProtQ62226|SHH_MOUSE Sonic hedgehog protein (Gene Name=Shh)

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