Structure of PDB 2wfr Chain A

Receptor sequence
>2wfrA (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
QLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFK
DEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQD
SLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKA
DNSLAVKLEHHHHHH
3D structure
PDB2wfr Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H141 D148 H183 H103 D110 H145
BS02 CA A E90 E91 D96 T126 E127 E52 E53 D58 T88 E89
BS03 CA A E91 E127 D130 E53 E89 D92
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:2wfr, PDBe:2wfr, PDBj:2wfr
PDBsum2wfr
PubMed19561611
UniProtO43323|DHH_HUMAN Desert hedgehog protein (Gene Name=DHH)

[Back to BioLiP]