Structure of PDB 2wel Chain A

Receptor sequence
>2welA (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKL
EREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY
SEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADF
GLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILL
VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPA
KRITASEALKHPWICQRSMMHRQETVDCLKKFNARRKLKGAILTTMLATR
NFSA
3D structure
PDB2wel Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D136 K138 E140 N141 D157 T177
Catalytic site (residue number reindexed from 1) D128 K130 E132 N133 D149 T169
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K88 A L20 A41 K43 D91 L92 V93 D157 L12 A33 K35 D83 L84 V85 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2wel, PDBe:2wel, PDBj:2wel
PDBsum2wel
PubMed20668654
UniProtQ13557|KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (Gene Name=CAMK2D)

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