Structure of PDB 2wdz Chain A

Receptor sequence
>2wdzA (length=254) Species: 1063 (Cereibacter sphaeroides) [Search protein sequence]
MDYRTVFRLDGACAAVTGAGSGIGLEICRAFAASGARLILIDREAAALDR
AAQELGAAVAARIVADVTDAEAMTAAAAEAEAVAPVSILVNSAGIARLHD
ALETDDATWRQVMAVNVDGMFWASRAFGRAMVARGAGAIVNLGSMSGTIV
NRPQFASSYMASKGAVHQLTRALAAEWAGRGVRVNALAPGYVATEMTLKM
RERPELFETWLDMTPMGRCGEPSEIAAAALFLASPAASYVTGAILAVDGG
YTVW
3D structure
PDB2wdz Structural Insight Into Substrate Differentiation of the Sugar-Metabolizing Enzyme Galactitol Dehydrogenase from Rhodobacter Sphaeroides D.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G22 S144 Y159 K163
Catalytic site (residue number reindexed from 1) G22 S144 Y159 K163
Enzyme Commision number 1.1.1.406: galactitol 2-dehydrogenase (L-tagatose-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G18 S21 G22 I23 D42 R43 A65 D66 V67 S92 A93 L142 S144 Y159 K163 P189 V192 T194 M196 T197 G18 S21 G22 I23 D42 R43 A65 D66 V67 S92 A93 L142 S144 Y159 K163 P189 V192 T194 M196 T197
BS02 1SP A S146 Y159 S146 Y159
BS03 1SP A A45 D49 R62 A45 D49 R62
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2wdz, PDBe:2wdz, PDBj:2wdz
PDBsum2wdz
PubMed20410293
UniProtC0KTJ6|GATDH_CERSP Galactitol 2-dehydrogenase (L-tagatose-forming)

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