Structure of PDB 2wdu Chain A

Receptor sequence
>2wduA (length=210) Species: 6192 (Fasciola hepatica) [Search protein sequence]
DKQHFKLWYFQFRGRAEPIRLLLTCAGVKFEDYQFTMDQWPTIKPTLPGG
RVPLLDVTGPDGKLRRYQESMAIARLLARQFKMMGETDEEYYLIERIIGE
CEDLYREVYTIFRTPQGEKEAKIKEFKENNGPTLLKLVSESLESSGGKHV
AGNRITLGDLFLFTTLTHVMETVPGFLEQKFPKLHEFHKSLPTSCSRLSE
YLKKRAKTPF
3D structure
PDB2wdu The 1.6 Angstrom Crystal Structure of the Fasciola Hepatica Sigma Class Gst
ChainA
Resolution1.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y10 R16 R21
Catalytic site (residue number reindexed from 1) Y9 R15 R20
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDS A R16 W41 K45 R52 V53 E70 S71 Y110 R15 W40 K44 R51 V52 E69 S70 Y109
BS02 GSH A F11 R16 W41 K45 R52 V53 E70 S71 F10 R15 W40 K44 R51 V52 E69 S70
BS03 GDS A D104 E108 N130 N131 D103 E107 N129 N130
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2wdu, PDBe:2wdu, PDBj:2wdu
PDBsum2wdu
PubMed
UniProtQ06A71

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