Structure of PDB 2wd1 Chain A

Receptor sequence
>2wd1A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKK
IHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSPLVVL
PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAA
RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT
QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY
CPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB2wd1 Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D147 A149 R151 N152 D165 A186
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZZY A I1084 V1092 A1108 L1157 Y1159 M1160 M1211 A1221 D1222 Y1230 I30 V38 A54 L100 Y102 M103 M154 A164 D165 Y173 MOAD: ic50=82nM
PDBbind-CN: -logKd/Ki=7.09,IC50=82nM
BindingDB: IC50=82nM
BS02 GBL A L1140 L1157 F1223 L1225 A1226 L86 L100 F166 L168 A169
BS03 GBL A F1089 R1227 D1228 M1229 Y1235 K1244 F35 R170 D171 M172 Y178 K187
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2wd1, PDBe:2wd1, PDBj:2wd1
PDBsum2wd1
PubMed19369077
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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